Welcome to iMAGO
Non-invasive Imaging Technologies for the Personalized Treatment of People with Obesity
We are a group of researchers willing to break new ground in the development and application of new metabolic phenotyping technologies applicable to humans and animals
Personalized diagnostic for the treatment of obesity
The Research Unit aims to further develop and apply new non-invasive imaging technologies based on optoacoustics and magnetic resonance for safe and longitudinal monitoring of parameters of energy and lipid metabolism, in particular in adipose tissue and muscle in vivo. This includes dynamic measurements of hemoglobin (oxygenated/deoxygenated), oxygen saturation rate, blood volume and flow rate, lipid profiles, as well as lipid and water content in cells and tissues. In pilot studies with participants with obesity, insulin-resistance and diabetes we will record and analyze the dynamic responses of these parameters during acute metabolic challenges (test meal, exposure to cold, training) in order to identify biomarkers for individual metabotypes. We will use and evaluate the new imaging technologies for detection and longitudinal monitoring of selected biomarkers in an intervention study with caloric restriction or exercise training. In particular, we are interested in biomarkers that reflect metabolic adaptations in muscle and fat tissue during the course of the intervention and are associated with positive changes in the systemic metabolic status. Our Research Unit will investigate the suitability of such biomarkers for personalizing lifestyle interventions. The long-term goal is the development of new diagnostic approaches through label-free measurement of the current metabolic status, which will create new possibilities in personalized nutrition and medicine for the treatment of overweight and obesity.
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